Tag Archives: tuberculosis

The tiny zebrafish has enabled some big advances in biomedical research, thanks in part to its optical transparency during embryonic stages, which allows for direct, microscopic visualization of biological processes in vivo in real time. Its latest contribution is to our understanding of tuberculosis, a disease in which pathogenic mycobacteria induce the formation of complexContinueContinue reading “A new view of tuberculosis”

Tuberculosis, caused by infection with Mycobacterium tuberculosis, is a leading cause of illness and death worldwide, killing >1 million people annually. Current treatment uses multiple drugs, lasts for months and is challenged by increasing drug resistance among strains. Mycobacterial drug resistance is mediated in part by efflux, a pumping mechanism that sheds drugs from theContinueContinue reading “A semi-synthetic approach to treat tuberculosis”

Tuberculosis is a serious public health concern, especially as emerging forms of the disease are increasingly resistant to existing drugs. Thus, the discovery of a synthetic compound with anti-tuberculosis activity in mice brings new hope that effective treatment of the disease is possible. Lab Anim. (NY) 42, 310 (2013). view full text (login required)