Tag Archives: obsession & compulsion

Obsessive-compulsive disorder (OCD) is a psychiatric disorder characterized by obsessive thoughts, compulsive repetitive actions and, often, anxiety and depression. Its underlying causes and pathology remain largely unknown, although a genetic component has been suggested. Now, scientists have identified a gene whose absence causes OCD-like behavior in mice. The gene encodes Slitrk5, a neuron-specific transmembrane proteinContinueContinue reading “Knocking out compulsive behavior”

An international group of scientists is delving into the genetic basis of obsessive-compulsive disorder (OCD) using mice that are genetically engineered to lack the gene Sapap3, which is involved in neurotransmitter signaling. Deleting Sapap3 resulted in greater anxiety and compulsive grooming to the point of self-injury in these mice. Both the anxiety and excessive groomingContinueContinue reading “Mice shed light on OCD”