lupus – Fluent in Science

Mutation of MDA5 in autoimmunity

MDA5 is an intracellular viral receptor that detects picornaviruses and other invaders and elicits immune responses accordingly. It has been implicated in autoimmune disorders such as type 1 diabetes, Crohn’s disease, psoriasis and systemic lupus erythematosus, but no mechanistic link has been identified. To learn more about its potential role in autoimmunity, Takashi Fujita (KyotoContinueContinue reading “Mutation of MDA5 in autoimmunity”

For lupus treatment, drug delivery may be key

Lupus is an autoimmune disorder in which the immune system becomes dysregulated, attacking the body’s own cells and tissues and causing inflammation and subsequent damage. Systemic lupus erythematosus (SLE) is the most common and serious form of lupus. There is no cure; treatments instead focus on suppressing the immune response in order to minimize organContinueContinue reading “For lupus treatment, drug delivery may be key”