The U.S. Food and Drug Administration [Public domain] via Wikimedia CommonsFor several years, the biomedical research community has recognized that compounds already approved for human use might have additional therapeutic applications. To facilitate investigation of new applications for existing drugs, the US National Institutes of Health (NIH) assembled several collections of molecules that can be screened for specific characteristics. Two recent papers report the screening of these collections together with animal testing to identify promising new uses for approved drugs.