US National Institute of Health [Public domain] via Wikimedia CommonsHIV can be effectively suppressed using antiretroviral therapy but surges back once therapy is stopped. Latent reservoirs of infected cells, invisible to the body’s immune system and impervious to drugs, cause the infection to rebound if therapy is terminated. Researchers at Rockefeller University (New York, NY) led by Michel Nussenzweig designed a new, two-part strategy to target latent viral reservoirs in the treatment of HIV infection.